SvenskaTheoretical pharmacology.
Since I do not have access to a laboratory, I continue with theoretical pharmacology. This is rather nice and convenient. But remember, these are hypothesis, so they are not accepted by the scientific society yet. It may take years.
I started my PhD studies in 1999 at the Department of Pharmacology, University of Gothenburg. I was rapidly introduced to scientific meetings and understood that Professor Arvid Carlsson had come up with beautiful ideas. He has given a historical review lecture. Here, the concept auto receptor is explained. Please, see the following link:
I went to the scientific meeting and listened. This was actually only 2-3 weeks from when I started at the department. I was asked what my subject was and I explained that I was going to study the relation between acetylcholine and dopamine with regard to ethanol reward. Since this subject was new to me I listened to the meeting.
What I remember from that meeting was that Professor Arvid Carlsson was curios about the existence of functional nicotinic acetylcholine auto receptors. I guess he mentioned that since I mentioned acetylcholine.
My subject was to study the role of various nicotinic acetylcholine receptor subunits involved in accumbal ethanol induced dopamine stimulation. At a very early stage, I performed dose-response on nicotinic antagonists on locomotor activity in mice. These are very kind experiments. It is important to remember that many people are involved in performing experiments. I have explained previously that you need a lot to do research: lab, research grants, staff etc. That is why I today only can do theoretical research.
One of the nicotinic antagonists was di-hydro-beta-erythroidine. These experiments are explained in (Larsson et al, 2002). And this finding is mentioned as “dose-finding experiments with no effect per se”.
Surprisingly, a biphasic dose response curve was demonstrated. And, since it is an antagonist, it was surprising to find that it stimulated locomotor activity. Clearly, to my opinion, there are feedback mechanisms.
The results of these experiment are documented at the Department of Pharmacology at University of Gothenburg. But, of course, they must be repeated, and be put in a broader perspective. This is, to my opinion, a very difficult and challenging subject. The reason I write about it is that I have a gut feeling that it is important.
In research there are always so many question asked. And there are so many hypothesis raised. The challenge is to sort out what is important.
This experiment has been in my mind for several years.
I think it is about two years ago. I saw a curve in a magazine. In economics. Completely different from pharmacology. That curve reminded me of that experiment and I started to think about the study. And I also had in mind what Professor Arvid Carlsson had talked about.
What is important to sort out, is that I am talking about functional nicotinic auto receptors. This is very difficult to demonstrate.
Ok, that is all for tonight. And please try to understand that I put a lot brain energy to this. I actually get headache of thinking sometimes.
And it is good to have good reading glasses 😉
Take care,
Anna
This, I wrote on FB.
Finns påskens motsvarighet till julnöt?
Jag kan inte låta bli att ha någonting att klura på.
Mina kunskaper inom ekonomi är ytterst modesta. Men vad jag har uppfattat så finns det cykler inom ekonomi så väl så som inom biologi. Precis som biologin, med årstidernas växlingar, månens skiftningar etc, så finns det kanske liknande skiftningar även inom ekonomi. Åtminstone känner jag till inflation och deflation. Depression verkar ju finnas både inom ekonomi och biologi.
Jag brukar ibland i nyheterna se, utifrån en lekmans ögon, hur aktiemarknaden ibland ökar och ibland minskar. Av en slump råkade jag se en aktiekurva som väldigt mycket liknade resultatet av ett experiment jag erhöll under studietiden. Den studien skulle kunna ha tolkats som ett funktionellt stöd för nicotinerga autoreceptorer.
Inom farmakologi så finns begreppet autoreceptor.
En receptor kan beskrivas som ett lås där rätt nyckel (en molekyl) kan öppna upp för en förändring i kroppen som resulterar i en anpassning till yttre och inre miljö. Det verksamma ämnet i ett läkemedel binder till en receptor.
För att finjustera förändringen finns t ex autoreceptorer som hjälper till att reglera aktiviteten. Allt strävar efter jämvikt lärde jag mig någon gång. Det här är ett väldigt komplext samspel som jag känner stor ödmjukhet inför.
Någonting jag har lärt mig under åren är att ju mer man läser, ju mer förstår man att man inte förstår.
Min påsknöt är:
går det att definiera autoreceptorer inom ekonomi?
Inser att det i så fall torde vara komplext eftersom jag känner till att det finns micro- och makroekonomi.
Finns de då som naturliga krafter och/eller sker finjustering via olika ekonomiska åtgärder?
???